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MIT Tech Review 100일 전

콜로설, 멸종 위기 붉은 늑대 복제 주장…사실일까?

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8/10
핵심 요약

생명공학 스타트업 콜로설 바이오사이언스가 멸종 위기에 처한 붉은 늑대(red wolf)를 복제했다고 발표하면서 학계에 큰 파장이 일고 있습니다. 늑대 보존을 담당하는 기존 연구진 및 동물원 협회조차 이 사실을 전혀 모르던 상태에서 비밀리에 진행된 이번 프로젝트는 그 진위와 복제 목적, 생태계 복원 가능성 등을 두고 과학자들 간의 치열한 논쟁을 촉발했습니다. 이는 '디익스팅션(멸종 방지 및 복원)' 기술의 상업적 적용이 생물다양성 보존 커뮤니티에 미칠 윤리적, 생태적 영향을 보여주는 중요한 사례입니다.

번역된 본문

늑대와 비슷한 무언가를 포획하고 싶다면 새벽녘之前에 출발하는 것이 가장 좋다. 그래서 올해 1월 어느 아침, 동쪽 지평선이 아직 분홍빛을 띠고 있을 때 나는 두 젊은 과학자와 함께 짙은 안개 속으로 운전해 들어갔다. 서쪽으로 40마일 떨어진 휴스턴의 공업 지대는 황금빛으로 빛나고 있었다. 태너 브루사드의 낡은 도요타 타코마 픽업트럭이 제방 위의 도로를 덜컹거리며 달렸고, 쉬고 있던 뻐꾸기가 깜짝 놀라 전조등 빛을 가로질러 날아올랐다. 브루사드는 함정을 찾으며 어둠 속을 응시했다. "여기 하나 있네요." 그가 속도를 약간 늦추며 말했다. 맥니즈 주립대학교的大學院生인 그는 조용하고 사색적인 성격이었고, 수염을 기른 얼굴은 검은 야구 모자 아래 절반쯤 가려져 있었다. "아무것도 없네." 그가 담담하게 말했다. 트럭은 계속 나아갔다.

늑대와 그들의 친척인 개, 자칼, 코요테 등은 개과(Canidae)로 분류되며, 텍사스 동부 이 지역을 지배했던 개과 동물은 바로 붉은 늑대(red wolf)였다. 하지만 백인 정착민들이 이 대륙에 도착하자마자 붉은 늑대(Canis rufus)는 위협에 직면했다. 늑대에 대한 전쟁은 "200년 동안 지속되었다"고 연방 연구원들은 놀랍도록 인상적인 보고서에서 밝혔다. "그리고 늑대가 패배했다." 1980년까지 야생 붉은 늑대는 멸종된 것으로 선언되었고, 그 개체군은 소수의 포획 사육 개체로만 줄어들었다. 그럼에도 불구하고 그 후 수십 년 동안 사람들은 멕시코만 연안을 따라 이상한 늑대 모양의 생물들이 계속 서식하고 있다는 사실을 알아차렸다. 마침내 2018년, 과학자들은 일부 지역 코요테가 단순한 코요테가 아니라는 것을 확인했다. 그들은 더 크고 다리가 길었으며, 계피빛이 도는 털을 가지고 있었다. 이 동물들은 잔존하는 붉은 늑대 유전자를 포함하고 있었다. 그들은 '유령 늑대(ghost wolves)'로 알려지게 되었다.

브루사드는 루이지애나주 남서부에서 자라며 코요테가 부모님의 목장을 터벅터벅 걸어 다니는 것을 지켜보았다. 이것들이 단순한 코요테가 아니라 그 이상의 무언가일 수 있다는 흥미로운 사실은 그의 방황하던 학업을 새로운 방향으로 이끌었다. 2023년, 7년간의 공백 끝에 대학으로 돌아온 브루사드는 늑대에 대한 싹트는 집착으로 인해 연구 초점을 좁혔다. 학사 학위를 마치기도 전에 그는 저명한 환경 보호 비영리 단체에 현장 데이터를 제공하기 시작했다. 그러다 작년, 석사 과정을 시작하기 직전 그는 당혹스러운 소식을 접했다.

콜로설 바이오사이언스(Colossal Biosciences)라는 스타트업이 1만 년 전에 멸종한 대형 개과 동물인 다이어 울프(dire wolf)를 부활시켰다고 주장한 것이다. 전문가들은 이 프로젝트의 유용성과, 유전적으로 약간 수정된 회색 늑대를 기술적으로 다이어 울프라고 부를 수 있는지에 대해 논쟁했다. 하지만 브루사드에게 중요한 것은 콜로설이 붉은 늑대 네 마리를 복제했다는 동시 발표였다. "그것은 늑대 연구 커뮤니티의 거의 모든 사람을 놀라게 했습니다." 브루사드가 우리가 그가 함정을 설치한 야생 동물 보호구역을 둘러보며 말했다. 미국 동물원 및 수족관 협회(AZA)는 포획 사육을 통해 붉은 늑대를 유지하는 프로그램을 운영하고 있었지만, 그 리더십조차 복제 프로젝트가 진행 중이라는 것을 전혀 몰랐다. 콜로설이 복제를 위한 DNA를 추출하는 데 사용한 개과 동물을 포획했던 브루사드의 지도교수 중 한 명인 생태학자 조이 힌턴도 몰랐다. 힌턴의 전 파트너 중 일부는 이 회사와 협력하고 있었지만, 그는 복제가 진행되고 있다는 사실을 몰랐다.

이미 과학자들 사이에서는 멸종 방지(de-extinction)라는 전체 아이디어에 대한 이견이 존재했다. 이제 콜로설은 위치가 비밀로 유지되는 이 신비로운 복제 늑대들을 만들었다. 일부 과학자들에게는 복제의 목적조차 불분명했다. 그들이 어떻게 붉은 늑대 개체군을 회복할 수 있을지도 불명확했다. 붉은 늑대는 항상 논쟁의 여지가 있는 종이었으며, 과학자들이 정확히 규명하기 어려운 존재였다. 붉은 늑대 연구 커뮤니티는 이미 소수이지만 열정적인 집단의 피할 수 없는 대인 관계 긴장으로 얼룩져 있었다. 이제 콜로설의 복제 늑대는 또 하나의 논쟁의 핵심이 되었다. 하지만 어쩌면 가장 흥미로운 질문은 이 회사가 실제로 붉은 늑대를 복제했는지 여부일 것이다.

북미 동부 지역의 늑대, 즉 텍사스에서 일리노이, 뉴욕에 이르기까지 숲과 초원, 습지를 배회했던 최상위 포식자인 붉은 늑대를 떠올려 보라. 회색 늑대보다 작고(코요테보다는 상당히 큰) 이...

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If you want to capture something wolflike, it’s best to embark before dawn. So on a morning this January, with the eastern horizon still pink-hued, I drove with two young scientists into a blanket of fog. Forty miles to the west, the industrial sprawl of Houston spawned a golden glow. Tanner Broussard’s old Toyota Tacoma bumped over the levee-top roads as killdeer, flushed from their rest, flew across the beams of his headlights. Broussard peered into the darkness, looking for traps. “I have one over here,” he said, slowing slightly. A master’s student at McNeese State University, he was quiet and contemplative, his bearded face half-hidden under a black ball cap. “Nothing on it,” he said, blandly. The truck rolled on. Wolves and their relations—dogs, jackals, coyotes, and so on—are classed in the family Canidae , and the canid that dominated this landscape in eastern Texas was once the red wolf. But as soon as white settlers arrived on the continent, Canis rufus found itself under siege. The war on wolves “lasted 200 years,” federal researchers once put it, in a surprisingly evocative report. “The wolf lost.” By 1980, the red wolf was declared extinct in the wild, its population reduced to a small captive breeding population. Still, for decades afterward, people noted that strange wolflike creatures persisted along the Gulf Coast. Finally, in 2018, scientists confirmed that some local coyotes were more than coyotes: They were taller, long-legged, their coats shaded with hints of cinnamon. These animals contained relict red wolf genes. They became known as the ghost wolves. Broussard grew up in southwest Louisiana, watching coyotes trot across his parents’ ranch. The thrilling fact that these might have been not just coyotes but something more? That reset a rambling academic career. In 2023, Broussard had recently returned to college after a seven-year pause, and his budding obsession with wolves narrowed his focus. Before he finished his bachelor’s degree, he began to supply field data to a prominent conservation nonprofit. Then, last year, just before he began his master’s studies, he woke to disconcerting news. A startup called Colossal Biosciences claimed to have resuscitated the dire wolf, a large canid that went extinct more than 10,000 years ago. Pundits debated the utility of the project and whether the clones—technically, gray wolves with some genetic tweaks—could really be called dire wolves. But what mattered to Broussard was Colossal’s simultaneous announcement that it had cloned four red wolves. “That surprised pretty much everybody in the wolf community,” Broussard said as we toured the wildlife refuge where he’d set his traps. The Association of Zoos and Aquariums runs a program that sustains red wolves through captive breeding; its leadership had no idea a cloning project was underway. Nor did ecologist Joey Hinton, one of Broussard’s advisors, who had trapped the canids Colossal used to source the DNA for its clones. Some of Hinton’s former partners were collaborating with the company, but he didn’t know that clones were on the table. There was already disagreement among scientists about the entire idea of de-extinction. Now Colossal had made these mystery clones, whose location was kept secret. Even the purpose of the clones was murky to some scientists; just how they might restore red wolf populations was unclear. Red wolves had always been a contentious species, hard for scientists to pin down. The red wolf research community was already marked by the inevitable interpersonal tensions of a small and passionate group. Now Colossal’s clones became one more lightning rod. Perhaps the most curious question, though, was whether the company had cloned red wolves at all. You can think of the red wolf as the wolf of the East—an apex predator that once roamed the forests and grasslands and marshes everywhere from Texas to Illinois to New York. Smaller than a gray wolf (though a good bit larger than a coyote), this was a sleek beast, with, according to one old field guide, a “cunning fox-like appearance”: long body, long legs; clearly built to run across long distances. Its coat was smooth and flat and came in many colors: a reddish tone that comes out in the right light, yes, but also, despite the name, white and gray and, in certain regions and populations, an ominous all black. We know these details thanks to a few notes from early naturalists. As writer Andrew Moore writes in his new book, The Beasts of the East , by the time a mammalogist decided to class these eastern wolves as a standalone species in the 1930s, the red wolf had been extirpated from the East Coast and was rapidly dwindling across its range. Working with remnant skulls and other specimens, the mammalogist chose the name red wolf—which was later enshrined with the Latinate Canis rufus— because that’s what these wolves were called in the last place they survived. The looming extinction of the red wolf turned out to be a good thing for coyotes. Canis latrans is a distant relative of wolves that split away from a common ancestor thousands of years ago and might be considered, as one canid biologist put it to me, the “wolf of the Anthropocene.” Their smaller size means they need less food and can survive in smaller and more fragmented territory, the kind that modern humans tend to build. The last red wolves, which lived in Louisiana and Texas, decided a strange and smaller mate was preferable to no mate at all. Red wolves had kept coyotes out of eastern America, outcompeting them for prey. Now, as the wolves declined, the coyotes began to slip in. The last red wolves, which lived in Louisiana and Texas, decided a strange and smaller mate was preferable to no mate at all. Soon the territory became a genetic jumble, home to both wolves and coyotes and hybrids that, after several generations of intermixing, came in every shade between. Scientists call such a population a “hybrid swarm,” and it poses a genetic threat to the declining species: As more coyotes poured east, and as all the canids kept interbreeding, there would be nothing that was “purely” wolf. For years, no one seemed to notice. Perhaps trappers in the region mistook the new hybrids for wolves—or were happy to take the higher bounty that a wolf pelt earned. Finally, though, by the 1960s, as the concept of endangered species first emerged, biologists began to worry for the disappearing wolf. The best solution they could come up with was a program of mass extermination. Over several years, trappers rounded up hundreds of canids in Texas and Louisiana. Those deemed true red wolves (on the basis of their howls and skull shape) were whisked away to breed in captivity. Most of the rest were euthanized. In 1980, the red wolf was declared extinct in the wild. To put it plainly: The red wolf was wiped out intentionally, in a roundabout effort to keep it alive. Just 14 individuals survived this gauntlet; today’s wolves descend from 12 of those. They became the ark, the source material for the few hundred red wolves that live today. There are about 280 in the “Species Survival Plan” population, living in captivity, and another 30 or so that roam a federal refuge in coastal North Carolina, and that the government deems “nonessential” and “experimental.” According to the US Fish and Wildlife Service, to be classified as a representative of the protected entity known as Canis rufus , an animal must trace at least 87.5% of its lineage to the 12 founders. The scientist who led this trapping-and-breeding program understood that the federal government would be narrowing the red wolf’s gene pool precipitously—so much so that the result could be an entirely new species. None of those notably black wolves persisted in the new population, for example. But what other choice existed? A new kind of wolf, free of the taint of the invading coyote, seemed better than no wolf at all. After I learned about Colossal’s clones, I decided to tr